造血細胞移植の成績を示すために、1991年1月から1997年12月までに第1回目の移植を受けた症例についての生存曲線を図1から図6に示した。生存曲線の計算にはKaplan-Meier法を用い、その検定にはLogrank test(各図の検定結果の右上、* p<0.05, ** p<0.01, *** p<0.001)と generalized Wilcoxon test (左下)を用いた。本解析は探索的な性格を持つ解析であるため、3群以上の生存曲線を示した場合でも、多重比較の補正は考慮に入れず各2群間での検定を行った。
「2.登録状況」で述べた如く、この生存曲線の解析には全国調査であるためのいくつかの制約があることを考慮に入れた上で結果を解釈して頂きたい。
なお、小児とあるのは年齢が15歳未満、成人とあるのは15歳以上を示す。図中の略語は以下の通りである。
Survival curves were calculated for patients who underwent a first stem cell transplant between January 1991 and December 1997 (Figures 1 to 6). The Kaplan-Meier method was adopted for curve estimation, and the Logrank test (shown in the upper right of each table for significance test, * p<0.05, ** p<0.01, *** p<0.001) and generalized Wilcoxon test (shown lower left) were used for test of significance. All analyses are the exploratory, so two sample tests have been performed without attempting multiple comparison, even when three or more groups are compared.
As described in "2. REGISTRATION", the survival analyses had several restrictions due to the nationwide survey. Accordingly, the results must be interpreted carefully.
Abbreviations in Figures are as below. “Children”in Figures means recipients younger than 15 years old, and “Adults”, those 15 years old or over.
| 1st CR | :First complete remission | 1回目寛解時 |
| 2nd CR | :Second complete remission | 2回目寛解時 |
| >3rd CR | :Third or subsequent complete remission | 3回目以降の寛解時 |
| allo-BMT | :allogeneic bone marrow transplant | 同種骨髄移植 |
| allo-PBSCT | :allogeneic peripheral blood stem cell transplant | 同種末梢血幹細胞移植 |
| AML | :Acute myelogenous leukemia | 急性骨髄性白血病 |
| ALL | :Acute lymphoblastic leukemia | 急性リンパ性白血病 |
| AP | :Accelerated phase of chronic myeloid leukemia | CMLの加速期 |
| ATL | :Adult T-cell leukemia | 成人T細胞白血病 |
| auto-BMT | :Autologous bone marrow transplant | 自家骨髄移植 |
| auto-PBSCT | :Autologous peripheral blood stem cell transplant | 自家末梢血幹細胞移植 |
| BC | :Blastic crisis of chronic myeloid leukemia | CMLの急性転化 |
| CML | :Chronic myelogenous leukemia | 慢性骨髄性白血病 |
| CP | :Chronic phase of chronic myeloid leukemia | CMLの慢性期 |
| GVHD | :graft-versus-host disease | 移植片対宿主病 |
| HD | :Hodgkin's disease | ホジキン病 |
| MDS | :Myelodysplastic syndrome | 骨髄異形性症候群 |
| NHL | :Non-Hodgkin lymphoma | 非ホジキンリンパ腫 |
| non-CR | :non-complete remission phase | 非寛解時 |
| unrel.-BMT | :BMT from unrelated donors | 非血縁者骨髄移植 |
| rel.-BMT | :BMT from relative other than sibling | 非同胞血縁者間骨髄移植 |
| sib.-BMT | :Bone marrow transplantation from sibling | 同胞間骨髄移植 |
| syn.-BMT | :Syngeneic bone marrow transplant | 一卵性同胞間骨髄移植 |
| Apla. | :Aplastic anemia | 再生不良性貧血 |
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